Research Focus:
The main research direction is the immune and genomic mechanism of inflammatory bowel disease and the pathogenesis of digestive system tumors, and a series of studies have been carried out with the goal of elucidating the pathogenesis of the disease: more than 20 academic papers have been published in journals such as Cancer Res, Oncogene, BBA and other journals as the first author/corresponding author. He gave 2 presentations at the American Gastroenterology Week Conference, poster exchanges many times, and 1 presentation at the World Gastroenterology Congress. In 2006, he won the National Outstanding Self-funded International Student Award of the Chinese Government and was awarded the top 10% outstanding abstract of the 2012 American Gastroenterology Week Conference. He has presided over 4 projects of the National Natural Science Foundation of China.
Main Research Areas:
Has been engaged in the clinical and research work of ocular surface and corneal diseases for a long time. Contains rich clinical experience and is a pioneer in the field of ocular surface and dry eye in China. It is the first in the world to propose the use of decellularization method to construct porcine tissue engineering cornea, and the first to report the successful clinical application of porcine tissue engineering cornea constructed by this method in the world. His main research interests include corneal and ocular surface diseases, including the mechanism of limbal stem cell proliferation and differentiation,diagnosis and treatment of dry eye and its product development, research and development of tissue-engineered cornea, application and mechanism study of amniotic membrane on ocular surface, pathogenesis of ocular surface neovascularization.
Educational background:
1989~1994: Beijing University of Chinese Medicine, Department of Traditional Chinese Medicine, Bachelor of Traditional Chinese Medicine
2000~2002: Training, Department of Japanese Language, Tokyo University of Foreign Chinese, Japan
2002~2006: Ph.D., Department of Gastroenterology, University of Tokyo
Work experience:
1994~2000: Department of Gastroenterology, Zhongmeng Hospital, Chifeng City, Inner Mongolia, Physician
2006~2009: Postdoctoral Fellow, Department of Gastroenterology, Massachusetts General Hospital, Harvard University
2009~Present: Department of Gastroenterology, School of Medicine, Xiamen University/Zhongshan Hospital, Associate Professor, Professor, Director of the Central Laboratory of Zhongshan Hospital
Selected Publications
1. Wang LF, Liu YS, Yang B, Li P, Cheng XS, Xiao CX, Liu JJ, Li S, Ren JL, Guleng B. The extracellular matrix protein mindin attenuates colon cancer progression by blocking angiogenesis via Egr-1-mediated regulation. Oncogene. 2018 Feb 1;37(5):601-615.；
2. Xiao CX, Xiao JJ, Xu HZ, Wang HH, Chen X, Liu YS, Li P, Shi Y, Nie YZ, Li S, Wu KC, Liu ZJ, Ren JL, Guleng B. Exome sequencing identifies novel compound heterozygous IFNA4 and IFNA10 mutations as a cause of impaired function in Crohn's disease patients. Sci Rep. 2015 May 22;5:10514.
3. Shi Y, Chen GB, Huang QW, Chen X, Liu JJ, Xu W, Huang XX, Liu YP, Xiao CX, Wu DC, Guleng B, Ren JL. miR218-5p regulates the proliferation of gastric cancer cells by targeting TFF1 in an Erk1/2-dependent manner. Biochim Biophys Acta. 2015 May;1852(5):970-9.
4. Chang SY, Song JH, Guleng B, Cotoner CA, Arihiro S, Zhao Y, Chiang HS, O'Keeffe M, Liao G, Karp CL, Kweon MN, Sharpe AH, Bhan A, Terhorst C, Reinecker HC. Circulatory antigen processing by mucosal dendritic cells controls CD8(+) T cell activation. Immunity. 2013 Jan 24;38(1):153-65.
5. Guleng B, Tateishi K, Ohta M, Kanai F, Jazag A, Ijichi H, Tanaka Y, Washida M, Morikane K, Fukushima Y, Yamori T, Tsuruo T, Kawabe T, Miyagishi M, Taira K, Sata M, Omata M. Blockade of the stromal cell-derived factor-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner. Cancer Res. 2005 Jul 1;65(13):5864-71.
