Research Focus：
Our laboratory focuses on the role of cellular stress in physiopathological processes. Key genes are mainly found using large-scale gene mutations and gene knockouts, and verified at the cellular level and on two model organisms: mice and fruit flies. The analyzation is made between role of these genes and their mediated signaling pathways in the stress response.
Cellular stress responses are the common responses of cells to different environmental stressors. External infection and stress response caused by internal lesions are important components of immune inflammation and play a very important role in the occurrence and development of many major human diseases , such as tumors.
The cellular stress response involves many physiological processes, and we intend to address the following questions:
1. The relationship between cellular stress response in cell differentiation, cellular senescence, apoptosis, and necrosis
2. The relationship between cell stress response and cell carcinogenesis-related signaling pathways.
3. The relationship between cell stress response and tumor cell metabolic pathway
4. The relationship between immune inflammation and diseases such as atherosclerosis, sepsis, enteritis and bowel cancer
Educational background:
1978-1982: Beijing University (Peking University), China, B.S., Specialty in Biochemistry
1982-1985: Beijing University (Peking University), China, M. S., Specialty in Protein Chemistry
1985-1990: University of Brussels (Université Libre de Bruxelles), Belgium, 1990, Ph.D., Specialty in Molecular Biology
Work experience:
1990-1992: Research Fellow, Department of Internal Medicine and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
1992-1993: Research Associate, Department of Immunology, The Scripps Research Institute,La Jolla, California, USA
1993-1996: Assistant Member, Department of Immunology, The Scripps Research Institute,La Jolla, California, USA
1996-2004: Associate Professor, Department of Immunology, The Scripps Research Institute,La Jolla, California, USA
2004-2007: Professor, Department of Immunology, The Scripps Research Institute,La Jolla, California, USA
2002- 2007: Adj. Professor, School of Life Sciences, Xiamen University, Xiamen, China
2007 to present: Professor, School of Life Sciences, Xiamen University, Xiamen, China. Dean, Faculty of Medicine and Life Sciences, Xiamen University, China. Director, State Key Laboratory of Cellular Stress Biology. Director,Innovation Center for Cell Signaling Network. Director,Laboratory Animal Center,Xiamen University,China. Vice President,Xiamen University,Xiamen,China
Selected Publications
1. He WT, Wan H, Hu L, Chen P, Wang X, Huang Z, Yang ZH,Zhong CQ,Han J.Gasdermin D is an executor ofpyroptosis and required for interleukin-1βsecretion. Cell Res. 2015 Dec; 25(12): 1285-98.
2. Li Y,Zhong CQ, Xu X,Cai S, Wu X, Zhang Y, Chen J, Shi J, Lin S,Han J. Group-DIA: analyzing multiple data-independent acquisition mass spectrometry data files. Nat Methods. 2015 Oct 5;12(12):1105-6.
3. Chen W, Wu J, Li L, Zhang Z, Ren J, Liang Y, Chen F, Yang C, Zhou Z, Sean Su S, Zheng X, Zhang Z,Zhong CQ, Wan H, Xiao M, Lin X, Feng XH,Han J. Ppm1b negatively regulates necroptosis through dephosphorylating Rip3. Nat Cell Biol. 2015; 17(4): 434-444.
4.Huang Z, Wu SQ, Liang Y, Zhou X, Chen W, Li L, Wu J, Zhuang Q, Chen C, Li J,Zhong CQ, Xia W, Zhou R, Zheng C,Han J. RIP1/RIP3 Binding to HSV-1 ICP6 Initiates Necroptosis to Restrict Virus Propagation in Mice. Cell Host & Microbe. 2015 ; 17(2): 229-42.
5.Chen X, Li W, Ren J, Huang D, He WT, Song Y, Yang C, Li W, Zheng X, Chen P,Han J. Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death. Cell Res. 2013; 24(1):105-21.
6. Zhang DW,Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J. 2009. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science325: 332-6
7. Sun P,Yoshizuka N, New L, Moser BA, Li Y, Liao R,Xie C, Chen J, Deng Q,Yamout M, Dong MQ,Frangou CG, Yates JR, 3rd, Wright PE, Han J. 2007. PRAK is essential forras-induced senescence and tumor suppression. Cell128: 295-308
8. Jing Q, Huang S,Guth S,Zarubin T,Motoyama A, Chen J, DiPadova F, Lin SC, Gram H, Han J. 2005. Involvement ofmicroRNA in AU-rich element-mediated mRNA instability.Cell120: 623-34
9.Ge B, Gram H, DiPadova F, Huang B, New L,Ulevitch RJ,Luo Y, Han J. 2002. MAPKK-independent activation of p38alpha mediated by TAB1-dependentautophosphorylation of p38alpha. Science295: 1291-4
10. Han J, Jiang Y, Li Z,Kravchenko VV,Ulevitch RJ. 1997. Activation of the transcription factor MEF2C by the MAPkinase p38 in inflammation. Nature386: 296-9
11. Han J, Lee JD,Bibbs L,Ulevitch RJ. 1994. A MAPkinase targeted byendotoxin andhyperosmolarity in mammalian cells. Science265: 808-11
