Research Focus:

Cell death plays a vital role in maintaining the body's homeostatic balance, and when cells die, cell membranes rupture and contents are released, which may lead to a large number of inflammatory responses, and uncontrolled inflammatory responses can lead to acute or chronic inflammatory and immune diseases. Although necrotic cells have long been found in inflamed tissues, it is only in recent years that its pro-inflammatory effects have gradually attracted attention with the deepening of the understanding of the mechanism of cell necrosis.

The main research directions of the laboratory are as follows:

(1) the regulatory mechanism of cell necrosis;

(2) the role of cell necrosis in inflammatory and immune diseases;

(3) The role of regulating cell necrosis pathways in the treatment of inflammatory and immune diseases.

Educational background:

2004~2008: Bachelor of Science in Biological Sciences, College of Life Sciences, Xiamen University

2008~2013: Ph.D. in Biochemistry and Molecular Biology, School of Life Sciences, Xiamen University

Work experience:

2013~2020: Postdoctoral Fellow, Institute of Genetics/CECAD Research Center, University of Cologne, Germany

2020.11~ present: Professor, School of Medicine, Xiamen University

Selected Publications

1. Lin J, Kumari S, Kim C, Van T-M, Wachsmuth L, Polykratis A & Pasparakis M (2016). RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation. Nature, 540: 124-128;

2. Lin J, Li H, Yang M, Ren J, Huang Z, Han F, Huang J, Ma J, Zhang D, Zhang Z, Wu J, Huang D, Qiao M, Jin G, Wu Q, Huang Y, Du J, Han J (2013). A role of RIP3-mediated macrophage necrosis in atherosclerosis development. Cell Rep., 3(1):200-210.

3. Jiao H, Wachsmuth L, Kumari S, Schwarzer R, Lin J, Eren RO, Fisher A, Lane R, Young GR, Kassiotis G, Kaiser WJ, Pasparakis M (2020). Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation. Nature. 580(7803):391-395.

4. Lin J, Kumari S, Kim C, Van T-M, Wachsmuth L, Polykratis A & Pasparakis M (2016). RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation. Nature, 540: 124-128;

5. Dannappel M, Vlantis K, Kumari S, Polykratis A, Kim C, Wachsmuth L, Eftychi C, Lin J, Corona T, Hermance N, Zelic M, Kirsch P, Basic M, Bleich A, Kelliher M & Pasparakis M (2014) RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis. Nature 513: 90–94

6. Lin J, Li H, Yang M, Ren J, Huang Z, Han F, Huang J, Ma J, Zhang D, Zhang Z, Wu J, Huang D, Qiao M, Jin G, Wu Q, Huang Y, Du J, Han J (2013). A role of RIP3-mediated macrophage necrosis in atherosclerosis development. Cell Rep., 3(1):200-210.

7. Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J is.(2009). RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science. 325(5938):332-6.

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