Research Focus：

To explore the pathogenesis of HIV-related cognitive disorders, and to find effective molecular targets for their treatment. Development of new protein drugs that can pass through the blood-brain barrier.

Educational background:

1980-1985: Bachelor of Traditional Chinese Medicine, Hebei Medical University

1999-2003: Ph.D. in Molecular Pathology and Molecular Genetics, Kagoshima University, Japan

Work experience:

1985.08-2006.10: Attending physician, Affiliated Hospital of Zhangjiakou Institute of Traditional Chinese Medicine, Hebei Province

1997.07-1999.03 Visiting Researcher, Kitakyushu Industrial Medical University, Japan

2003.10-2004.01: Assistant Professor, Kagoshima University, Japan

 2004.02-2006.10: Postdoctoral Fellow, Institute of Viral Diseases, Faculty of Medicine, Kagoshima University, Japan

 2007.10-2008.09: Foreign Researcher, Kagoshima University, Japan

 2009.07-present: Professor, School of Medicine, Xiamen University

Selected Publications

1、Xing HQ, Moritoyo T, Mori K, Tadakuma K, Sugimoto C, Ono F, Hayakawa H, Izumo S.Simian immunodeficiency virus encephalitis in the white matter and degeneration of the cerebral cortex occur independently in simian immunodeficiency virus-infected monkey. J NeuroVirology.2003

2、Arisato T, Okubo R, Arata H, Abe K, Fukada K, Sakoda S, Shimizu A, Qin XH, Izumo S, Osame M, Nakagawa M. Clinical and pathological studies of  familial amyotrophic lateral sclerosis (FALS) with SOD1 H46R mutation in large Japanese families. Acta Neuropathol. 2003

3、Izumo S, Kubota R, Xing HQ. Retrovirus infection and neurological disorders. No To Shinkei. 2006

4、Xing HQ, Mori K, Sugimoto C, Ono F, Izumo K, Kuboda R, Izumo S. Impaired Astrocytes and Diffuse Activation of Microglia in the Cerebral Cortex in Simian Immunodeficiency Virus-infected Macaques Without Simian Immunodeficiency Virus Encephalitis.J Neuropathol Exp Neurol.2008; 67:600-611

5、Xing HQ, Hayakawa H, Gelpi E, kubota R, Budka H, Izumo S. Reduced expression of excitatory amino acid transporter-2 (EAAT-2) and diffuse activation of microglia in the cerebral cortex of AIDS brains both with and without HIV encephalitis. J Neuropathol Exp Neurol. 2009; 68:199-209

6、Xing HQ, Hayakawa H, Izumo K, kubota R, Gelpi E, Budka H, Izumo S. In vivo expression of proinflammatory cytokines in HIV encephalitis: an analysis of 11 autopsy cases. Neuropathology. 2009; 29: 433-442. (Corresponding author)

7、Xing HQ, Moritoyo T, Mori K, Sugimoto C, Ono F, Izumo S. Expression of proinflammatory cytokines and its relationship with virus infection in the brain of macaques inoculated with macrophage-tropic simian immunodeficiency virus. Neuropathology. 2009; 29: 13-19. (Corresponding author)

8、Aye MM, Kasai T, Tashiro Y, Xing HQ, Shirahama H, Mitsuda M, Suetsugu T, Tanaka K, Osame M, Izumo S. CD8 positive T-cell infiltration in the dentate nucleus of paraneoplastic cerebellar degeneration. J Neuroimmunol. 2009; 208: 136-140.

9、H Zheng, R Tang, Y Yao, Z Ji, Y Gao, Z Liu, F Peng, W Wang, C Dan, H Xing, G Bu, H Xu, Y Zhang, W Zheng. MiR-219 Protects Against Seizure in the Kainic Acid Model of Epilepsy. Mol Neurobiol 2014 Nov 15.

10、J Wang, Y Yin, X Wang, H Pei, S Kuai, L Gu, H Xing, Y Zhang, Q Huang, B Guan,Ratioof monocytes to lymphocytes in peripheral blood in patients diagnosed withactive Tuberculosis, Braz J infect dis, 2015.19(2): 125-131.

11、H Xing, Y Zhang, K Izumo, S Arishima, R Kubota, X Ye, Q Xu, K Mori, S Izumo. Decrease of aquaporin-4 and excitatory amino acid transporter-2 indicate astrocyte dysfunction for pathogenesis of cortical degeneration in HIV-associated neurocognitive disorders. Neuropathology, 2016.(Corresponding author)

1、国际合作研究重大项目，中国福建省沿岸地域和西南日本HTLV-1感染所致疾病的比较，中方项目负责人，2016.04-2019.03

2、国家自然科学基金,HIVTat抑制EAAT-2表达参与HAD发生的分子机制, 2013.01-2016.12 

3、福建省自然科学基金项目,HIVTat诱导ADC神经元凋亡的作用机制,2013.01-2016.3

4、国际合作研究项目,中国福建省沿岸地域和西南日本HTLV-1感染所致疾病的比较, 中方项目负责人,2013.04-2016.03 

5、日本教育部科研经费，艾滋病及艾滋脑病发病机理及治疗,2007.10～2008.09

6、厦门大学引进人才科研启动项目，AQP4在艾滋痴呆综合征中的发病机制，2010.01～2012.12