Research Focus：
Professor Wang Yan has long been engaged in cardiovascular translational medicine research, mainly interested in cardiac interventional clinical research, atherosclerotic mechanism and clinical research, ischemia-reperfusion injury and myocardial protection, cardiac stem cell research, ion channels and arrhythmia pathogenesis, cardiac interventional clinical research, atherosclerotic mechanism and the therapeutic effect of traditional Chinese medicine active ingredients on cardiovascular diseases. In recent years, he has published more than 20 papers in internationally renowned journals as the first/corresponding author; It has undertaken more than 10 national, provincial and municipal scientific research projects such as the key projects of the National Natural Science Foundation of China and the key research and development projects of the Ministry of Science and Technology, with scientific research funds exceeding 20 million yuan.
Educational background:
1985-1990: Bachelor of Clinical Medicine, Xi'an Medical University
1993-1996: Master of Cardiology, Xinjiang Medical University
1999-2004: Ph.D., Department of Cardiology, Faculty of Medicine, The University of Hong Kong
Work experience:
1990-1996: Resident physician, Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University
1996-2001: Registered Physician, Department of Cardiology, Queen Mary Hospital, Hong Kong
2002-2003: Registered Physician, Department of Cardiology, St. Paul's Hospital, Hong Kong
2001-2014: Chief Physician, Department of Cardiology, Zhongshan Hospital, Xiamen University
2015-2016: President of Xiamen Cardiovascular Hospital (Xiamen Heart Center).
2016-present: President of Xiamen University Cardiovascular Hospital (Xiamen Heart Center).
Scientist in the Research and Development Department at TissueTech, Inc. Miami, USA
July 1999 - May 2003: Attending physician, Department of Ophthalmology, Songgang People's Hospital, Shenzhen, Guangdong Province
Selected Publications
1. Du, Qian., Qian, Ming-Ming., Liu, Pin-Li., Zhang, Le.Wang Y. Liu, Dong-Hui, . Glycation of high-density lipoprotein triggers oxidative stress and promotes the proliferation and migration of vascular smooth muscle cells. J Geriatr Cardiol. 2017;14(7), 473-480 [Abstract]
2. Liu, Donghui., Ding, Zhenzhen., Wu, Mengzhang., Xu, Wenqi., Qian, Mingming., Du, Qian. Wang Yan#. the apolipoprotein A-I mimetic peptide, D-4F, alleviates ox-LDL-induced oxidative stress and promotes endothelial repair through the eNOS/HO-1 pathway . J. Mol. Cell. Cardiol.l. 2017; 105, 77-88 [Abstract] IF=5.67
3. Deng, Xiu-Ling., Wang, Yan., Xiao, Guo-Sheng. Effects of equol on multiple K+ channels stably expressed in HEK 293 cells. PLoS ONE. 2017;12(8), e0183708.[Abstract]
4. Li G, Wang Y#,,Li GR..Bradykinin regulates cell growth and migration in cultured human cardiac c-Kit+ progenitor cells. Oncotarget.. 2017 Feb 14;8(7):10822-10835.[Abstract] IF=5.167
5. Xiao GS, Zhang YH, Wu W, Sun HY, Wang Y, Li GR.Genistein and tyrphostin AG556 decrease human atrial ultra-rapidly activating delayed rectifier potassium current by inhibiting EGFR tyrosine kinase. Br J Pharmacol.. 2017 Mar;174(6):454-467.[Abstract] IF=IF=5.259
6. Jie LJ, Wu WY, Li G, Xiao GS, Zhang ST, Li GR,Wang Y#.Clemizole hydrochloride blocks cardiac potassium channels stably expressed in HEK293 cells. Br J Pharmacol.. 2017 Feb ;174(3).[Abstract] IF=IF=5.259.
7. Wang Y, Wang Y#, Li GR. TRPC1/TRPC3 channels mediate lysophosphatidylcholine-induced apoptosis in cultured human coronary artery smooth muscles cells. Oncotarget. 2016 Jul 26.[Full Text] [Abstract] IF=5.008
8. Liu H, Yang L, Wu HJ, Chen KH, Lin F, Li G, Sun HY, Xiao GS, Wang Y, Li GR. Water-soluble acacetin prodrug confers significant cardioprotection against ischemia/reperfusion injury. Sci Rep. 2016; 6: 36435. [Full Text] [Abstract] IF=5.228
9. Liu H, Wang YJ, Yang L, Zhou M, Jin MW, Xiao GS, Wang Y, Sun HY, Li GR. Synthesis of a highly water-soluble acacetin prodrug for treating experimental atrial fibrillation in beagle dogs. Sci Rep. 2016; 6: 25743. [Full Text] [Abstract] IF=5.228
10. Che H, Xiao GS, Sun HY, Wang Y#, Li GR. Functional TRPV2 and TRPV4 channels in human cardiac c-Kit+ progenitor cells. J Cell Mol Med. 2016; 20: 1118-27. [Abstract] IF=4.938
11. Liu H, Yang L, Chen KH, Sun HY, Jin MW, Xiao GS, Wang Y#, Li GR. SKF-96365 blocks human ether-à-go-go-related gene potassium channels stably expressed in HEK 293 cells. Pharmacol Res. 2016; 104: 61-69. [Abstract] IF=4.816
12. Chen KH, Xu XH, Sun HY, Du XL, Liu , Yang L, Xiao GS .Wang Y, Jin MW, Li GR. Distinctive property and pharmacology of voltage-gated sodium current in rat atrial versus ventricular myocytes. Heart Rhythm. 2016; 13: 762-70. [Abstract] IF=4.319
13. Cheng Y, Zhou M, Wang Y. Arctigenin antagonizes mineralocorticoid receptor to inhibit the transcription of Na/K-ATPase. J Recept Signal Transduct Res. 2016; 36: 181-8. [Abstract]
14. Che H, Li G, Sun HY, Xiao GS, Wang Y, Li GR. Roles of store-operated Ca2+ channels in regulating cell cycling and migration of human cardiac c-Kit+ progenitor cells. Am J Physiol Heart Circ Physiol. 2015; 30: H1772-81. [Abstract] IF=3.324
15. Wang B, Wang Y#. Acute coronary syndrome caused by left main coronary artery compression between the aortic root and massive dilation of the left atrium. Can J Cardiol. 2015; 31: 227. [Abstract] IF=3.112
16. Zhang YY, Li G, Che H, Sun HY, Xiao GS, Wang Y#, Li GR. Effects of BKCa and Kir2.1 channels on cell cycling progression and migration in human cardiac c-Kit+ progenitor cells. PLoS One. 2015; 10: e0138581. [Abstract] IF=3.057.
17. Chen SL, Xu B, Han YL, Sheiban I, Zhang JJ, Ye F, Kwan TW, Paiboon C, Zhou YJ, Lv SZ, Dangas GD, Xu YW, Wen S, Hong L, Zhang RY, Wang HC, Jiang TM, Wang Y, Sansoto T, Chen F, Yuan ZY, Li WM, Leon MB. Clinical outcome after DK crush versus Culotte stenting of distal left main bifurcation lesions: the 3-year follow-up results of the DKCRUSH-III study. JACC Cardiovasc Interv. 2015; 8: 1335-42. [Abstract] IF=7.63
13. Zhang YY, Li G, Che H, Sun HY, Li X, Au WK, Xiao GS, Wang Y#, Li GR. Characterization of functional ion channels in human cardiac c-Kit+ progenitor cells. Basic Res Cardiol. 2014; 109: 407. [Abstract] IF=6.038.
14. Wang Y*, Ji L, Jiang R, Zheng L, Liu D. Oxidized high-density lipoprotein induces the proliferation and migration of vascular smooth muscle cells by promoting the production of ROS. J Atheroscler Thromb. 2014; 21: 204-16. [Abstract] [Full text] IF=2.459.
15. Wang B, Wang Y#, Ye T, Xiao G, Chang H, Wen H, Chen Y, Lin J, Yang L, Ye J, Huang L, Chen L, Cui Y, Fan C, Wu Y, Zheng Q. Integrated regional network construction for ST-segment elevation myocardial infarction care. Zhong Hua Xin Xue Guan Bing Za Zhi. 2014; 42: 650-4. [Abstract]
16. Sun HY, Xiao GS, Wang Y, Li GR. Ionic mechanism underlying distinctive excitability in atrium and ventricle of the heart. Sheng Li Xue Bao. 2014 25; 66: 85-95. [Abstract]
17. Chen SL, Xu B, Han YL, Sheiban I, Zhang JJ, Ye F, Kwan TW, Paiboon C, Zhou YJ, Lv SZ, Dangas GD, Xu YW, Wen SY, Hong L, Zhang RY, Wang HC, Jiang TM, Wang Y, Chen F, Yuan ZY, Li WM, Leon MB. Comparison of double kissing crush versus Culotte stenting for unprotected distal left main bifurcation lesions: results from a multicenter, randomized, prospective DKCRUSH-III study. J Am Coll Cardiol. 2013; 61: 1482-8. [Abstract] IF=17.759
18. Chang H, Wang Y, Wu W, Li G, Hanawa H, Zou J . Hydrodynamics-based delivery of an interleukin-1 receptor II fusion gene ameliorates rat autoimmune myocarditis by inhibiting IL-1 and Th17 cell polarization. Int J Mol Med. 2013; 31: 833-40. [Abstract] IF=2.459.
