Research focus:Mainly engaged in research on T cell function and corresponding molecular mechanisms under normal and diseased conditions, including T cell development, activation and differentiation, tumor immunity, anti infective immunity, and autoimmune diseases. Through close cooperation with clinical doctors, conduct research on the pathogenesis and immunotherapy of related diseases.As an early user of mass spectrometry flow cytometry (CyTOF) and mass spectrometry imaging (IMC) in China, we have been committed to the development of relevant reagents and the innovation of experimental methods in recent years, hoping to combine the optimized mass spectrometry flow cytometry with traditional flow cytometry to conduct more accurate and rapid in-depth analysis of rare clinical samples.
Education Background:
1999/06-2004/08, PhD, Department of Microbiology and Immunology, University of Melbourne, Australia
1995/09-1998/06, Department of Immunology, China Medical University, Master
1991/09-1995/07, Department of Biology, Liaoning University, Bachelor's degree
Work experience:
December 2019 - present, Xiamen University School of Medicine/State Key Laboratory of Cell Stress Biology, Professor
2014/10-2019/12, State Key Laboratory of Cell Stress Biology, School of Life Sciences, Xiamen University, Professor
2010/11-2014/08 Staff Scientist, Department of Immunology and Microbiology, Scripps Research Institute, USA
2004/10-2010/10 Postdoctoral Fellow, Department of Immunology and Microbiology, Scripps Research Institute, USA
1998/07-1999/06, Assistant Professor, Department of Immunology, China Medical University
Selected Publications:
1. Yang Q*, Chen K*, Zhang L*, Feng L, Fu G, Jiang S, Bi S, Lin C, Zhou Y, Zhao H, Chen XL, Fu G#, Xu B#. Synthetic lethality of combined AT-101 with idarubicin in acute myeloid leukemia via blockade of DNA repair and activation of intrinsic apoptotic pathway. Cancer Letters. 2019 Oct 1;461:31-43.
2. Huang J*, Alexey S*, Li J*, Jones T, Grande G, Douthit L, Xie J, Chen D, Wu X, Michael M, Xiao C, Zhao J, Xie X, Xie J, Chen XL#, Fu G#, Alexander G#, Tzeng CM#. Unique CDR3 epitope targeting by CAR-T cells is a viable approach for treating T-cell malignancies. Leukemia. 2019 Sep;33(9):2315-2319.
3. Shan W*, Zheng H*, Fu G, Liu C, Li Z, Ye Y, Zhao J, Xu D, Sun L, Wang X, Chen XL, Bi S, Ren L#, Fu G#. Bioengineered Nanocage from HBc Protein for Combination Cancer Immunotherapy. Nano Letters.2019 Feb 11.
4. Zheng S, Li H, Lai K, Chen M, Fu G, Liu WH, Fu G#, Nie L#. Noninvasive photoacoustic and fluorescent tracking of optical dye labeled T cellular activities of diseased sites at new depth. J Biophotonics. 2018 Sep;11(9):e201800073.
5.Ma Z*, Zhao X*, Huang J*, Jia X, Deng M, Cui D, Du Z, Fu G#, Ouyang G#, Xiao C#. A critical role of periostin in B-cell acute lymphoblastic leukemia. Leukemia. 2017 Aug;31(8):1835-1837
6.Liu WH#, Kang SG, Huang Z, Wu CJ, Jin HY, Maine CJ, Liu Y, Shepherd J, Sabouri-Ghomi M, Gonzalez-Martin A, Xu S, Hoffmann A, Zheng Y,Lu LF, Xiao N, Fu G#, Xiao C#. A miR-155-Peli1-c-Rel pathway controls the generation and function of T follicular helper cells. Journal of Experimental Medicine. 2016 Aug 22;213(9):1901-19.
7.Fu G, Casas J, Rigaud S, Rybakin V, Lambolez F, Brzostek J, Hoerter JAH, Paster W, Acuto O, Cheroutre H, Sauer K, Gascoigne NR. Themis sets the signal threshold for positive and negative selection in T cell development. Nature. 2013 Dec 19;504(7480):441-5.
8.Fu G*, Vallée S*, Rybakin V, McGuire MV, Ampudia J, Brockmeyer C, Salek M, Fallen PR, Hoerter JA, Munshi A, Huang YH, Hu J, Fox HS, Sauer K, Acuto O, Gascoigne NR. Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling.Nature Immunology. 2009 Aug;10(8):848-56.
9. Kong KF*, Fu G*, Zhang Y, Yokosuka T, Casas J, Canonigo-Balancio A, Becart S, Kim G, Yates JR 3rd, Kronenberg M, Saito T, Gascoigne NR, Altman A. Protein Kinase C-η Controls CTLA-4-Mediated Regulatory T Cell Function. Nature Immunology.2014 May;15(5):465-72.
10.FuG#, HuJ, Niederberger-MagnenatN, RybakinV, Casas J, YachiPP, FeldsteinS, MaB, HoerterJAH, AmpudiaJ, RigaudS, LambolezF, GavinAL, SauerK, CheroutreH, GascoigneNRJ#. Protein Kinase C η Is Required for T Cell Activation and Homeostatic Proliferation. Science Signaling. 2011 Dec 6;4(202):ra84.
11.Fu G#, Gascoigne NR#. Multiplexed labeling of samples with cell tracking dyes facilitates rapid and accurate internally controlled calcium flux measurement by flow cytometry.Journal of Immunological Methods. 2009 Oct 31;350(1-2):194-9.
12.Fu G, Rybakin V, Brzostek J, Paster W, Acuto O, Gascoigne NR. Fine- tuning T cell receptor signaling to control T cell development. Trends in Immunology. 2014 Jul;35(7):311-318. doi: 10.1016/j.it.2014.05.003. Epub 2014 Jun 17. Review.
