Research focus:Microglia are unique immune effector cells in the central nervous system (CNS), accounting for approximately 5-10% of the adult brain cell population and 10-20% of the total number of glial cells. In recent years, multiple genes specifically expressed on microglia, such as TREM2 and CSF1R, have been closely related to the occurrence of neurodegenerative diseases. Our research team aims to elucidate the role of these genes in regulating the function of microglia, their abnormal involvement in the molecular mechanisms of neurodegenerative diseases such as AD, and to search for prevention and treatment strategies for these diseases.
Education Background:
1993.09~1998.06 Bachelor of Medicine in Hubei Xianning Medical College Clinical Medicine Specialty ;
2002.09~2005.12 Master of Science in Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology;
2006.09~2009.07, Doctor of Medicine, Human Anatomy and Histology, Tongji Medical College, Huazhong University of Science and Technology;
2013.09~2014.10 Postdoctoral Fellow in Neuroscience at Mayo Clinic, USA
Work experience:
1998.09~2009.07 Assistant and Lecturer of Xianning Medical College, Hubei Province;
2009.08-2012.07 Assistant Professor, School of Medicine, Xiamen University;
2012.08-2020.07 Associate Professor, School of Medicine, Xiamen University;
2020.08-present Professor, Medical School, Xiamen University
Selected Publications:
1. Baoying Cheng, Xin Li, Kai Dai, Shengshun Duan, Zhouyi Rong, Yingmin Chen, Liangcheng Lü, Zhaoji Liu, Xiaohua Huang, Huaxi Xu, Yun-Wu Zhang*, Honghua Zheng*. Triggering receptor expressed on myeloid cells-2 (TREM2) interacts with colony-stimulating factor 1 receptor (CSF1R) but is not necessary for CSF1/CSF1R-mediated microglia survival.Front Immunol. 2021. Accepted.
2. Rong Z, Cheng B, Zhong L, Ye X, Li X, Jia L, Li Y, Shue F, Wang N, Cheng Y, Huang X, Liu CC, Fryer JD, Wang X, Zhang YW, Zheng H*. Activation of FAK/Rac1/Cdc42-GTPase signaling ameliorates impaired microglial migration response to Aβ42 in triggering receptor expressed on myeloid cells 2 loss-of-function murine models. FASEB J. 2020;34(8):10984-10997.
3. Zheng H*, Jia L, Liu CC, Rong Z, Zhong L, Yang L, Chen XF, Fryer JD, Wang X, Zhang YW, Xu H, Bu G*. TREM2 promotes microglial survival by activating Wnt/β-catenin pathway. J Neurosci. 2017; 37(7): 1772-1784.
4. Zheng H, Liu CC, Atagi Y, Chen XF, Jia L, Yang L, He W, Zhang X, Kang SS, Rosenberry TL, Fryer JD, Zhang YW, Xu H, Bu G*. Opposing Roles of the Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) and TREM-like Transcript 2 (TREML2) in Microglia Activation. Neurobiol Aging. 2016; 42:132-141.
5.Zheng H, Tang R, Yao Y, Ji Z, Cao Y, Liu Z, Peng F, Wang W, Can D, Xing H, Bu G, Xu H, Zhang YW*, Zheng W*. MiR-219 Protects Against Seizure in the Kainic Acid Model of Epilepsy. Mol Neurobiol. 53(1):1-7. 2016.
