Uterine myoma and Endometrial carcinoma
Research Focus：Whole-exome sequencing in patients with premature ovarian insufficiency - Early detection and early intervention
Premature ovarian insufficiency (POI) in women, linked to multiple diseases and genetically heterogeneous with unclear etiology in most cases, was studied. Whole - exome sequencing (WES) was done on POI patients' DNA samples, and detected variants were verified by Sanger sequencing and analyzed in - silico. Among 24 patients, 14 had POI - related gene variants, while 29 non - POI controls had none. Identifying genetic causes can boost patient compliance with interventions. The study confirmed POI's genetic heterogeneity, with WES as a potent tool for finding genetic causes, beneficial for genetic counseling and early POI detection and intervention.
Educational background:
September 1997 - July 2002: Norman Bethune Memorial university, Bachelor's degree in Clinical Medicine.
September 2002 - June 2005: Jilin University, Master's degree in Obstetrics and Gynecology
Work experience:
August 2005 - Present: Department of Gynecology，Women and Children's Hospital Of Xiamen University.
Selected Publications:
1.Liu H, Wei X, Sha Y, Liu W, Gao H, Lin J, Li Y, Tang Y, Wang Y, Wang Y, Su Z. Whole-exome sequencing in patients with premature ovarian insufficiency: early detection and early intervention. J Ovarian Res. 2020 Sep 22;13(1):114. doi: 10.1186/s13048-020-00716-6. PMID: 32962729; PMCID: PMC7510158.(Whole-exome sequencing in patients with premature ovarian insufficiency: early detection and early intervention - PubMed (nih.gov))
2.Wang Y, Xu Q, Cai J, Zheng L, Zuo W, Liu J, Cao J, Lin M, Liu H, Ye H.Performance verification and clinical evaluation of the NAP-Fluo Cycler system for detecting five genital tract pathogens based on microfluidic technology. Pract Lab Med. 2024 Jun 14;40:e00417. doi: 10.1016/j.plabm.2024.e00417. PMID:39022638; PMCID: PMC11252926.(Performance verification and clinical evaluation of the NAP-Fluo Cycler system for detecting five genital tract pathogens based on microfluidic technology - PubMed (nih.gov))
