Teaching Courses:
Asphyxia & Neonatal Resuscitation
Hypoxic-Ischemic Encephalopathy & Intracranial Hemorrhage
Research Focus：Neonatal respiration and Neonatal nutrition
Application of exosomes from umbilical cord mesenchymal stem cells for preventing and treating of bronchopulmonary dysplasia (BPD). Bronchopulmonary dysplasia (BPD) is the most common complication of prematurity, affecting about one-third of infants born less than 1.5 kg and less than 29 weeks gestational age. BPD is characterized by abnormal bronchial and bronchiolar mucosal metaplasia and hyperplasia, decreased number of alveoli, and abnormal vascular organization, leading to a chronic disease that affects the lung parenchyma, pulmonary circulation, and brain development.
Many biologic effects of MSCs are mediated by the extracellular vesicles (EVs) they secrete. MSC EVs have been shown to prevent and reverse pulmonary hypertension in multiple animal models where they increase the number of peripheral pulmonary vessels and the number of antiinflammatory macrophages. Considering the prominent roles that lung injury and pulmonary vascular remodeling play in the pathogenesis of BPD, MSC EVs may have unique advantages over other immunosuppressive therapies for this disease. Indeed, several labs have used this approach to attenuate lung injury in animal models of BPD.
Educational Background:
September 2009 - July 2014: Tongji Medical College, Southern Medical University, Master and Doctor's degree in Neonatology.
Work Experience:
July 2014 - Present: Department of Neonatology, Xiamen Maternity and Child Care Hospital, Xiamen University, Fujian, China.
Selected Publications:
（link to PubMed for all publications）
[1] Shen W, Wu F, Mao J, et al. Analysis of "True Extrauterine Growth Retardation" and Related Factors in Very Preterm Infants -A Multicenter Prospective Study in China. Frontiers in Pediatrics, 2022, 10:876310.
[2] Shen W#, Kuang P#, Wang B, et al. Genetic polymorphisms of LPCAT1, CHPT1 and PCYT1B and risk of neonatal Respiratory Distress Syndrome among Chinese Han population. Pediatrics and Neonatology, 2020, 61(3):318-324.
[3] Shen W, Xu X, Lee TF, et al. The Relationship Between Heart Rate and Left Ventricular Isovolumic Relaxation During Normoxia and Hypoxia-Asphyxia in Newborn Piglets. Frontiers in Physiology, 2019, 10: 525.
[4] Shen W, Du J, Wang B, et al. Analysis of nitric oxide synthase gene polymorphisms in neonatal respiratory distress syndrome among the Chinese Han population. Italian Journal of Pediatrics. 2014, 40(1):27.
[5] Wang Y#, Shen W#, Wu F, et al. Factors Influencing extrauterine growth retardation in singleton-non-small for gestational age of preterm infants in China: A prospective multicenter study. Pediatrics and Neonatology, 2022, 63(6):590-598.
[6] Huang X#, Shen W#, Wu F, et al. Real world evidence regarding the growth of very premature infants with small for gestational age after birth a multicenter survey in China. BMC Pediatrics, 2023 Aug 31;23(1):437.
[7] Gao L#, Shen W#, Wu F, et al. Effect of early initiation of enteral nutrition on short-term clinical outcomes of very premature infants: A national multicenter cohort study in China. Nutrition, 2023, 107:111912.
